Effects of Statins on Circulating Oxidized Low-density Lipoprotein in Patients With Hypercholesterolemia
نویسندگان
چکیده
منابع مشابه
Effect of extracorporeal low-density lipoprotein elimination on circulating cell adhesion molecules in patients with hypercholesterolemia.
L of circulating cell adhesion molecules (cCAM) may be useful markers for stratifying cardiovascular disease severity or prognosis.1–4 Furthermore, cCAM levels are elevated in subjects with insulin resistance, type 2 diabetic patients, hypertensive patients, and in smokers.5–11 The reported effects of hypercholesterolemia on cCAM levels, however, has been controversial.12–15 Sampietro and colle...
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The integrin heterodimer CDllb/CD18 (alphaMbeta2, Mac-1, CR3) expressed on monocytes or polymorphonuclear leukocytes (PMN) is a receptor for iC3b, fibrinogen, heparin, and for intercellular adhesion molecule (ICAM)-1 on endothelium, crucially contributing to vascular cell interactions in inflammation and atherosclerosis. In this report, we summarize our findings on the effects of lipid mediator...
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Oxidized low-density lipoprotein (OxLDL) and autoantibodies to OxLDL (aOxLDL) are implicated in the development of atherosclerosis. The objective of this study was to determine the importance of these factors in hypertension, a major risk factor for atherosclerosis. Samples were obtained from 111 men with established hypertension (diastolic pressure >95 mmHg) from the Swedish component of an on...
متن کاملEffects of rosuvastatin on low-density lipoprotein cholesterol and plasma lipids in Asian patients with hypercholesterolemia.
AIMS Rosuvastatin is more efficacious than other statins in lowering low-density lipoprotein cholesterol (LDL-C). Studies showing higher blood levels in Asians have resulted in concerns regarding increased adverse drug reactions. This study aimed to evaluate the efficacy and safety of rosuvastatin in hypercholesterolemic Asian patients. METHODS This retrospective observational study was condu...
متن کاملMeasuring circulating oxidized low-density lipoprotein to evaluate coronary risk.
The hypothesis that oxidized LDL (ox-LDL) is necessary, if not obligatory, in the development of atherosclerotic lesions was formulated .20 years ago with the seminal observation that uptake of native LDL by macrophages did not result in foam cell formation. In contrast, uptake of ox-LDL via scavenger receptors resulted in the unregulated accumulation of lipid.1 Since then, multiple studies in ...
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ژورنال
عنوان ژورنال: Japanese Heart Journal
سال: 2004
ISSN: 0021-4868,1348-673X
DOI: 10.1536/jhj.45.969